<![CDATA[Closelooknet: Longevity]]>https://substack.closelook.net/s/longevityhttps://substackcdn.com/image/fetch/$s_!8J27!,w_256,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fca964d2b-ee5c-48b7-b05e-62d366d41c94_1280x1280.pngCloselooknet: Longevityhttps://substack.closelook.net/s/longevitySubstackThu, 30 Jul 2026 05:45:30 GMT<![CDATA[Low-Dose Lithium: The Longevity Mineral Hiding in Your Drinking Water]]>https://substack.closelook.net/p/low-dose-lithium-the-longevity-mineralhttps://substack.closelook.net/p/low-dose-lithium-the-longevity-mineralThu, 19 Feb 2026 09:13:55 GMT

Lithium users had 3.6 times lower chances of dying at any given age compared to users of other psychiatric medications. Not in a small trial — in a UK Biobank cohort of over half a million people.

That finding alone should have made headlines. It didn’t. Because lithium carries baggage — decades of association with heavy psychiatric dosing, toxicity moni…

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]]><![CDATA[Rapamycin May Delay Aging, Reduce Disease, and Increase Lifespan]]>https://substack.closelook.net/p/rapamycin-may-delay-aging-reduce-d0chttps://substack.closelook.net/p/rapamycin-may-delay-aging-reduce-d0cSat, 19 Oct 2024 07:36:44 GMTAs progress in longevity science continues to accelerate, some researchers have started to investigate three innovative strategies that may be able to delay aging, reduce disease, and increase lifespan.

Rapamycin, mTOR, and Autophagy are at the forefront of the life extension revolution.

Closelooknet is a reader-supported publication. To receive new posts…

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]]><![CDATA[When Your Immune Function Falls Off the Cliff]]>https://substack.closelook.net/p/immune-function-falls-off-cliffhttps://substack.closelook.net/p/immune-function-falls-off-cliffWed, 16 Oct 2024 15:05:00 GMTImmune senescence is a leading cause of disability and infectious death in aging humans. By way of example, deaths from pneumonia are rare in youth but spiral upward as humans mature.

If you read obituaries (as I do), the number of once-vigorous individuals who perish from opportunistic illnesses caused by immune senescence is startling.

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What you need to know

  • Around age 60, physiological changes decimate our ability to combat infections and malignancies.

  • Immune senescence is a leading cause of disability and death in aging humans.

  • Nutrients that boost immune activity include zinc, DHEA, and fish oil.

  • Immune imbalance occurs when our immune system fails to protect against new infections and instead generates inflammatory reactions (including increased IL-6) that attack every cell in our body.

  • The herb Cistanche helps combat immune senescence, which appears to have rejuvenating effects on bone marrow.

  • Supplementation with Cistanche has been shown to increase naïve T cells and natural killer (NK) cells while decreasing memory T cells and pro-inflammatory IL-6.

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]]><![CDATA[Taurine: The Elixir of Longevity for Worms, Mice, and Monkeys, But What About Humans?]]>https://substack.closelook.net/p/taurine-ambrosia-longevity-worm-mouse-monkey-humanhttps://substack.closelook.net/p/taurine-ambrosia-longevity-worm-mouse-monkey-humanWed, 09 Oct 2024 07:54:00 GMTAccording to recent studies, Taurine, an amino acid used by bodybuilders and added to energy and sports drinks, may be an “ambrosia of longevity,” for worms, mice, and monkeys.

Whether the findings can be applied to humans is a matter of current scientific debate.

(1) KEY POINTS

  • Aging involves a range of physiological transformations, from the smallest org…

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]]><![CDATA[ The effects of caloric restriction mimetics on lifespan and healthspan.]]>https://substack.closelook.net/p/healthier-longer-effects-caloric-restriction-mimetics-lifespan-healthspanhttps://substack.closelook.net/p/healthier-longer-effects-caloric-restriction-mimetics-lifespan-healthspanWed, 02 Oct 2024 11:00:00 GMTCaloric Restriction (CR) avoiding malnutrition is the most thoroughly and successfully researched method to increase both – lifespan and healthspan – in a broad range of animals and non-human primates to date.

Caloric restriction mimetics (CRMs) are compounds or interventions that mimic the beneficial health and longevity effects of caloric restriction w…

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]]><![CDATA[Fighting the mTOR Syndrome - Rapamycin may delay aging, reduce disease, and increase lifespan]]>https://substack.closelook.net/p/fighting-mtor-syndrome-rapamycin-may-delay-aging-reduce-disease-increase-lifespanhttps://substack.closelook.net/p/fighting-mtor-syndrome-rapamycin-may-delay-aging-reduce-disease-increase-lifespanThu, 26 Sep 2024 14:07:00 GMTAs progress in longevity science continues to accelerate, some researchers have started to investigate three innovative strategies that may be able to delay aging, reduce disease, and increase lifespan.

Rapamycin, mTOR, and Autophagy are at the forefront of the life extension revolution.

The life extension revolution - a harmonious blend of biotechnology …

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]]><![CDATA[Poor Sleep Linked to Increased Risk of Earlier Mortality]]>https://substack.closelook.net/p/poor-sleep-linked-to-increased-riskhttps://substack.closelook.net/p/poor-sleep-linked-to-increased-riskThu, 19 Sep 2024 11:01:00 GMTOctober 14, 2024

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