<?xml version="1.0" encoding="UTF-8"?><rss xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:content="http://purl.org/rss/1.0/modules/content/" xmlns:atom="http://www.w3.org/2005/Atom" version="2.0" xmlns:itunes="http://www.itunes.com/dtds/podcast-1.0.dtd" xmlns:googleplay="http://www.google.com/schemas/play-podcasts/1.0"><channel><title><![CDATA[Closelooknet: Longevity]]></title><description><![CDATA[Weekend reads on the science of living longer and better. Longevity research, healthspan breakthroughs, and what the evidence actually says.]]></description><link>https://substack.closelook.net/s/longevity</link><image><url>https://substackcdn.com/image/fetch/$s_!8J27!,w_256,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fca964d2b-ee5c-48b7-b05e-62d366d41c94_1280x1280.png</url><title>Closelooknet: Longevity</title><link>https://substack.closelook.net/s/longevity</link></image><generator>Substack</generator><lastBuildDate>Mon, 15 Jun 2026 02:37:45 GMT</lastBuildDate><atom:link href="https://substack.closelook.net/feed" rel="self" type="application/rss+xml"/><copyright><![CDATA[Thomas Look - Closelook Venture ]]></copyright><language><![CDATA[en]]></language><webMaster><![CDATA[closelooknet@substack.com]]></webMaster><itunes:owner><itunes:email><![CDATA[closelooknet@substack.com]]></itunes:email><itunes:name><![CDATA[Thomas Look]]></itunes:name></itunes:owner><itunes:author><![CDATA[Thomas Look]]></itunes:author><googleplay:owner><![CDATA[closelooknet@substack.com]]></googleplay:owner><googleplay:email><![CDATA[closelooknet@substack.com]]></googleplay:email><googleplay:author><![CDATA[Thomas Look]]></googleplay:author><itunes:block><![CDATA[Yes]]></itunes:block><item><title><![CDATA[Low-Dose Lithium: The Longevity Mineral Hiding in Your Drinking Water]]></title><description><![CDATA[Research Evidence is Building Up]]></description><link>https://substack.closelook.net/p/low-dose-lithium-the-longevity-mineral</link><guid isPermaLink="false">https://substack.closelook.net/p/low-dose-lithium-the-longevity-mineral</guid><dc:creator><![CDATA[Thomas Look]]></dc:creator><pubDate>Thu, 19 Feb 2026 09:13:55 GMT</pubDate><enclosure url="https://substackcdn.com/image/fetch/$s_!aT9_!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fba7f3997-e855-4703-ade8-52943ac6ed7a_802x730.png" length="0" type="image/jpeg"/><content:encoded><![CDATA[
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   ]]></content:encoded></item><item><title><![CDATA[Rapamycin May Delay Aging, Reduce Disease, and Increase Lifespan]]></title><description><![CDATA[Fighting the mTOR Syndrome. As progress in longevity science continues to accelerate, some researchers have started to investigate three innovative strategies that may be able to delay aging, reduce disease, and increase lifespan.]]></description><link>https://substack.closelook.net/p/rapamycin-may-delay-aging-reduce-d0c</link><guid isPermaLink="false">https://substack.closelook.net/p/rapamycin-may-delay-aging-reduce-d0c</guid><dc:creator><![CDATA[Thomas Look]]></dc:creator><pubDate>Sat, 19 Oct 2024 07:36:44 GMT</pubDate><enclosure url="https://substackcdn.com/image/fetch/$s_!Anwm!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F557afc38-4dae-46d9-bbe7-76256b8bcb2f_1024x1024.png" length="0" type="image/jpeg"/><content:encoded><![CDATA[
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   ]]></content:encoded></item><item><title><![CDATA[When Your Immune Function Falls Off the Cliff]]></title><description><![CDATA[Immune senescence is a leading cause of disability and infectious death in aging humans. By way of example, deaths from pneumonia are rare in youth but spiral upward as humans mature. If you read obituaries (as I do), the number of once-vigorous individuals who perish from opportunistic illnesses caused by immune senescence is startling.k@Longevity]]></description><link>https://substack.closelook.net/p/immune-function-falls-off-cliff</link><guid isPermaLink="false">https://substack.closelook.net/p/immune-function-falls-off-cliff</guid><dc:creator><![CDATA[Thomas Look]]></dc:creator><pubDate>Wed, 16 Oct 2024 15:05:00 GMT</pubDate><enclosure url="https://substack-post-media.s3.amazonaws.com/public/images/f16d6ebf-519c-42cc-b284-9dd27cab5eea_720x720.png" length="0" type="image/jpeg"/><content:encoded><![CDATA[<p>Immune senescence is a leading cause of disability and infectious death in aging humans. By way of example, deaths from pneumonia are rare in youth but spiral upward as humans mature. </p><p>If you read obituaries (as I do), the number of once-vigorous individuals who perish from opportunistic illnesses caused by immune senescence is startling.</p><p class="button-wrapper" data-attrs="{&quot;url&quot;:&quot;https://substack.closelook.net/subscribe?&quot;,&quot;text&quot;:&quot;Subscribe now&quot;,&quot;action&quot;:null,&quot;class&quot;:null}" data-component-name="ButtonCreateButton"><a class="button primary" href="https://substack.closelook.net/subscribe?"><span>Subscribe now</span></a></p><h2>What you need to know</h2><ul><li><p><em>Around age 60, physiological changes decimate our ability to combat infections and malignancies.</em></p></li><li><p><em>Immune senescence is a leading cause of disability and death in aging humans.</em></p></li><li><p><em>Nutrients that boost immune activity include zinc, DHEA, and fish oil.</em></p></li><li><p><em>Immune imbalance occurs when our immune system fails to protect against new infections and instead generates inflammatory reactions (including increased IL-6) that attack every cell in our body.</em></p></li><li><p><em>The herb&nbsp;Cistanche&nbsp;helps combat immune senescence, which appears to have rejuvenating effects on bone marrow.</em></p></li><li><p><em>Supplementation with&nbsp;Cistanche&nbsp;has been shown to increase nai&#776;ve T cells and natural killer (NK) cells while decreasing memory T cells and pro-inflammatory IL-6.</em></p></li></ul><p class="button-wrapper" data-attrs="{&quot;url&quot;:&quot;https://substack.closelook.net/p/immune-function-falls-off-cliff?utm_source=substack&utm_medium=email&utm_content=share&action=share&quot;,&quot;text&quot;:&quot;Share&quot;,&quot;action&quot;:null,&quot;class&quot;:null}" data-component-name="ButtonCreateButton"><a class="button primary" href="https://substack.closelook.net/p/immune-function-falls-off-cliff?utm_source=substack&utm_medium=email&utm_content=share&action=share"><span>Share</span></a></p><h2></h2>
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   ]]></content:encoded></item><item><title><![CDATA[Taurine: The Elixir of Longevity for Worms, Mice, and Monkeys, But What About Humans?]]></title><description><![CDATA[Exploring the Potential Benefits of Taurine on Longevity in Various Species and Its Implications for Human Health.]]></description><link>https://substack.closelook.net/p/taurine-ambrosia-longevity-worm-mouse-monkey-human</link><guid isPermaLink="false">https://substack.closelook.net/p/taurine-ambrosia-longevity-worm-mouse-monkey-human</guid><dc:creator><![CDATA[Thomas Look]]></dc:creator><pubDate>Wed, 09 Oct 2024 07:54:00 GMT</pubDate><enclosure url="https://substack-post-media.s3.amazonaws.com/public/images/6c58fc4c-4f36-4bc1-a4d7-f67058bda1fd_1024x1024.png" length="0" type="image/jpeg"/><content:encoded><![CDATA[
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   ]]></content:encoded></item><item><title><![CDATA[ The effects of caloric restriction mimetics on lifespan and healthspan.]]></title><description><![CDATA[Healthier for Longer! Caloric Restriction (CR) avoiding malnutrition is the most thoroughly and successfully researched method to increase both &#8211; lifespan and healthspan &#8211; in a broad range of animals and non-human primates to date.Caloric restriction mimetics (CRMs) are compounds or interventions that mimic the beneficial health and longevity effects of caloric restriction without requiring a reduced caloric intake.]]></description><link>https://substack.closelook.net/p/healthier-longer-effects-caloric-restriction-mimetics-lifespan-healthspan</link><guid isPermaLink="false">https://substack.closelook.net/p/healthier-longer-effects-caloric-restriction-mimetics-lifespan-healthspan</guid><dc:creator><![CDATA[Thomas Look]]></dc:creator><pubDate>Wed, 02 Oct 2024 11:00:00 GMT</pubDate><enclosure url="https://substack-post-media.s3.amazonaws.com/public/images/3e0f3c66-aa83-4ff9-a99b-53f0b4f7e5a5_720x720.png" length="0" type="image/jpeg"/><content:encoded><![CDATA[
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   ]]></content:encoded></item><item><title><![CDATA[Fighting the mTOR Syndrome - Rapamycin may delay aging, reduce disease, and increase lifespan]]></title><description><![CDATA[Fighting the mTOR Syndrome. As progress in longevity science continues to accelerate, some researchers have started to investigate three innovative strategies that may be able to delay aging, reduce disease, and increase lifespan.Rapamycin, mTOR, and Autophagy are at the forefront of the life extension revolution.]]></description><link>https://substack.closelook.net/p/fighting-mtor-syndrome-rapamycin-may-delay-aging-reduce-disease-increase-lifespan</link><guid isPermaLink="false">https://substack.closelook.net/p/fighting-mtor-syndrome-rapamycin-may-delay-aging-reduce-disease-increase-lifespan</guid><dc:creator><![CDATA[Thomas Look]]></dc:creator><pubDate>Thu, 26 Sep 2024 14:07:00 GMT</pubDate><enclosure url="https://substack-post-media.s3.amazonaws.com/public/images/cf3408b9-c3c0-497f-9acb-b51744184fc3_1024x1024.png" length="0" type="image/jpeg"/><content:encoded><![CDATA[
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   ]]></content:encoded></item><item><title><![CDATA[Poor Sleep Linked to Increased Risk of Earlier Mortality]]></title><description><![CDATA[Individuals with inadequate sleep face a multitude of health challenges, such as elevated dementia risks and unintended weight gain.]]></description><link>https://substack.closelook.net/p/poor-sleep-linked-to-increased-risk</link><guid isPermaLink="false">https://substack.closelook.net/p/poor-sleep-linked-to-increased-risk</guid><dc:creator><![CDATA[Thomas Look]]></dc:creator><pubDate>Thu, 19 Sep 2024 11:01:00 GMT</pubDate><enclosure url="https://substackcdn.com/image/fetch/$s_!MQu5!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4e5a04ff-be4c-4ae7-a4c3-e7c075f3e9ea_1000x1000.png" length="0" type="image/jpeg"/><content:encoded><![CDATA[
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